The Colorado Avalanche have followed a five-game winning streak with three straight losses, and the past two losses were especially painful.

In a span of 48 hours, Colorado has lost its top goaltender, a first-line forward and a third-line grinder to significant injuries that will keep all three out for multiple weeks. The latest injury, to winger Mikko Rantanen, is a tough blow for a team that was a win away from taking over the top spot in the Western Conference over the weekend.

Now the Avalanche are limping into their matchup against the New York Islanders on Wednesday night, which wraps up a five-game homestand that hasn't gone well. Colorado blew a two-goal lead to Washington last week, dropped an outdoor game in the final minute to the struggling Los Angeles Kings and fell in overtime to the Tampa Bay Lightning on Monday night.